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固态核磁共振揭示了TDP-43胺基因区域在发电时的结构转变

Xiao-Feng Zhuo1,2,3, Jian Wang1, Jing Zhang1,2,3

  • 1School of Life Science and Technology , ShanghaiTech University , Shanghai 201210 , People's Republic of China.

Journal of the American Chemical Society
|February 1, 2020
PubMed
概括

作为ALS和FTLD等神经退行性疾病的标志,TDP-43蛋白聚合涉及从螺旋到β链的结构转变. 液-液相分离 (LLPS) 在粉体形成之前,特定的残留物相互作用稳定了有毒纤维.

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