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Updated: Aug 14, 2026

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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将转基因细胞移植到受损的大脑:NGF表达的恢复作用

M B Rosenberg1, T Friedmann, R C Robertson

  • 1Department of Pediatrics, University of California School of Medicine, La Jolla 92093.

Science (New York, N.Y.)
|December 16, 1988
PubMed
概括

使用经过改造以产生神经生长因子 (NGF) 的纤维细胞进行基因转移,可以防止神经元死亡,并促进大鼠的轴突生长,这表明潜在的中枢神经系统治疗.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...