在丹麦,神经疾病与自杀死亡的关联
Annette Erlangsen1,2,3,4, Egon Stenager5,6,7,8, Yeates Conwell9
1Danish Research Institute for Suicide Prevention, Mental Health Centre Copenhagen, Copenhagen, Denmark.
JAMA
|February 5, 2020
概括
患有神经障碍的人自杀率高于一般人群. 这种风险在诊断后不久就升高,特别是在亨廷顿病和肌缩侧面硬化症等疾病中.
科学领域:
- 神经学
- 精神病学
- 公共卫生
背景情况:
- 神经系统疾病与增加自杀风险有关.
- 需要对各种神经疾病进行全面评估.
研究的目的:
- 调查与普通人群相比,神经疾病患者的自杀率.
- 检查神经诊断与自杀之间的时间关联.
主要方法:
- 丹麦 (1980-2016) 全国回顾性队列研究,包括超过730万人.
- 分析神经疾病和相关自杀数据的医疗记录.
- 使用波桑回归估计的调整后的发病率比率 (IRR).
主要成果:
- 患有神经障碍的人的自杀率高出1. 8倍 (IRR=1. 8).
- 在肌性侧面硬化 (4. 9),亨廷顿病 (4. 9),多发性硬化 (2. 2),头部损伤 (1. 7), (1. 7) 和中风 (1. 3) 中观察到较高的IRR.
- 自杀风险在诊断后的前1-3个月内最高 (IRR=3. 1),随着时间的推移而下降,但仍然很高.
结论:
- 在被诊断患有神经疾病的人群中, 自杀率显著上升.
- 虽然总体绝对风险差异很小,但特定的疾病和早期诊断后的时期需要有针对性的关注.
- 这些发现强调了对神经病患者的心理健康支持的重要性.
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