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Updated: Dec 29, 2025

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HPF1补充了DNA损伤诱导的ADP-ribosylation的PARP活性位点

Marcin J Suskiewicz1, Florian Zobel1, Tom E H Ogden2

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Nature
|February 7, 2020
PubMed
概括

HPF1与PARP1/PARP2形成一个复合活性位点,该位点对于通过血清ADP-ribosylation修复DNA损伤至关重要. 这种相互作用对细胞对DNA损伤和临床PARP抑制剂的反应至关重要.

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