自然选择对大米基因表达的强度和模式
Simon C Groen1, Irina Ćalić2, Zoé Joly-Lopez1
1Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Nature
|February 14, 2020
概括
米的基因表达水平在潮湿条件下表现出较弱的选择,但在干旱条件下表现出较强的选择. 较低的表达,较高的可塑性和较少的网络连接与更强的选择相关.
科学领域:
- 进化生物学
- 分子遗传学
- 植物科学
背景情况:
- 基因表达水平是有机体表型的基础.
- 选择在适应性进化中的基因表达作用在很大程度上是未知的.
- 了解基因表达的选择对于破译进化过程至关重要.
研究的目的:
- 量化作用于大米 (Oryza sativa) 基因表达水平的选择类型和强度.
- 研究环境条件 (潮湿与干旱) 如何影响转录的选择.
- 识别与更强的选择相关的分子特征并探索它们的适应意义.
主要方法:
- 在大米中测试了15000多个基因表达.
- 使用表型选择分析来估计选择差异和优势.
- 使用多变量分析来评估基因表达网络和光合作用基因的选择.
主要成果:
- 大多数转录在潮湿条件下表现出中性或弱稳定性选择;在干旱条件下选择加剧.
- 具有较低表达,较高随机噪声和更高可塑性的转录受到更强的选择.
- 干旱条件被选为早期开花和增加OsMADS18基因的表达,将其确定为干旱逃生基因.
结论:
- 选择显著影响基因表达水平,环境条件调节其强度和目标.
- 像表达水平,噪声和可塑性这样的转录特性会影响它们对选择的易感性.
- 这项研究为估计分子特征的选择提供了一个框架,为适应性进化提供了见解.
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