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点击 蛋白质原子研究中的化学

Christopher G Parker1, Matthew R Pratt2

  • 1Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA.

Cell
|February 16, 2020
PubMed
概括

生物直角反应,就像点击化学一样,可以精确地研究蛋白质与小分子的相互作用和修饰. 这推动了蛋白质组分析,克服了传统生物方法的局限性,以获得更深入的细胞洞察力.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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