抗病毒迪特尔A和B的不同合成
Jiachen Deng1, Yuhan Ning1, Hailong Tian1
1CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
研究人员合成了新型抗病毒化合物,即维克罗尔A和B, 具有独特的化环结构. 这项研究证实了它们的结构,并证明了这些强大的流感病毒抑制剂的可行合成途径.
科学领域:
- 有机化学
- 自然产品合成
- 医学化学
背景情况:
- 维克罗尔A和B是二烯天然产品,具有独特的化6-5-6-6环框架.
- 这些化合物对H1N1流感A病毒具有显著的抗病毒活性.
研究的目的:
- 开发A和B的不同合成.
- 确认A和B的绝对配置.
主要方法:
- 由商业上可用的西托拉克开始合成.
- 关键步骤包括SmI2调节循环,克莱森重组和分子内化/阿尔多尔反应.
- 实现了四环核的立体控制组装.
主要成果:
- 分别在16个和15个步骤中成功合成了甲基和乙基.
- 合成途径有效地构建了复杂的四环结构.
- 证实了A和B的绝对配置.
结论:
- 建立了A和B的实用和有效的合成策略.
- 合成提供了这些强大的抗病毒药物以供进一步研究.
- 这项工作验证了结构性分配,并为探索相关的自然产品提供了基础.
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