皮肤软化剂和早期补充养以预防婴儿皮炎 (PreventADALL):一个因子,多中心,集群随机试验
Håvard Ove Skjerven1, Eva Maria Rehbinder2, Riyas Vettukattil1
1Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Lancet (London, England)
|February 23, 2020
概括
早期使用皮肤软化剂和引入补充食品并没有预防婴儿的亚托皮炎. 这项研究没有发现证据支持这些干预措施来预防12个月的湿疹.
科学领域:
- 皮肤病学
- 儿童医学
- 过敏免疫学
背景情况:
- 婴儿的皮肤护理和养做法是预防亚托皮炎和食物过敏的潜在目标.
- 之前的研究表明早期软化剂和补充养对高危婴儿有好处.
研究的目的:
- 调查从2周或早期补充养开始定期使用皮肤软化剂是否能在12个月的婴儿群体中减少亚托皮炎.
主要方法:
- 一个基于人群的2x2因子随机临床试验,涉及2397名婴儿.
- 婴儿被分配到:没有干预,皮肤软化剂,早期补充养或组合干预.
- 被蒙面的研究人员在3,6和12个月后对亚托皮炎进行评估.
主要成果:
- 在12个月后,亚托皮炎发生在8%的对照组,11%的皮肤干预组,9%的食物干预组和5%的联合干预组中.
- 皮肤软化剂和早期补充养都没有显著减少亚托皮炎的发展.
- 这些干预措施没有发现安全问题.
结论:
- 早期应用皮肤软化剂和早期引入补充食品并不能预防12个月大龄的婴儿群体的亚托皮炎.
- 目前的证据不支持这些干预措施用于婴儿的亚托皮炎的初级预防.
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