孕期母体肠道微生物对小鼠后代代谢表型的影响
Ikuo Kimura1,2, Junki Miyamoto3,2, Ryuji Ohue-Kitano3,2
1Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan. ikimura@cc.tuat.ac.jp hase-kj@pha.keio.ac.jp.
Science (New York, N.Y.)
|February 29, 2020
概括
母体肠道微生物通过产生指导胚胎细胞发育的短链脂肪酸来影响后代的新陈代谢. 这种对母体微生物的影响对于预防后代代谢综合征至关重要.
科学领域:
- 微生物学
- 发育生物学
- 代谢过程
背景情况:
- 肠道微生物群影响疾病易感性,但其胚胎作用尚不清楚.
- 母体肠道微生物群对后代发育的影响还未得到充分研究.
研究的目的:
- 研究母体微生物群对后代胚胎发育和代谢系统的影响.
- 探索母体肠道微生物塑造后代代谢健康的机制.
主要方法:
- 使用了小鼠模型,包括无细菌和传统养的后代.
- 分析了短链脂肪酸及其受体 (GPR41,GPR43) 在胚胎发育中的作用.
主要成果:
- 源自母体微生物群的SCFA调节胚胎神经,肠道和胰腺细胞分化.
- 没有细菌的母亲的后代在出生后更容易患上代谢综合征.
- 孕产妇的微生物影响对于建立产后能量平衡至关重要.
结论:
- 在胚胎发育过程中,母亲的肠道微生物群在塑造后代的新陈代谢系统中起着至关重要的作用.
- 这项研究强调了母体肠道环境与代谢综合征发育起源之间的关键联系.
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