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通过自动处理的Caspases在Pyroptosis中准GSDMD的结构机制

Kun Wang1, Qi Sun2, Xiu Zhong1

  • 1Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences, 102206 Beijing, China; National Institute of Biological Sciences, Beijing, 102206 Beijing, China.

Cell
|February 29, 2020
PubMed
概括

炎症酶激活的卡斯帕斯 (卡斯帕斯-1, -4, -11) 切割了Gasdermin D (GSDMD),从而引发了热. 这项研究揭示了激活的caspase-4/11如何使用独特的疏水接口来结合GSDMD,驱动热并提供新的治疗点.

关键词:
类植物卡斯帕斯-1卡斯帕斯- 11细胞死亡气体皮质炎症组天生的免疫力脂聚糖类形成孔隙的蛋白质热症

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