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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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  3. 具有高活性1d纳米孔的可降解孔的palladium纳米片用于低毒瘤的协同光疗
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  3. 具有高活性1d纳米孔的可降解孔的palladium纳米片用于低毒瘤的协同光疗

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具有高活性1D纳米孔的可降解孔的Palladium纳米片用于低毒瘤的协同光疗

Shanshan Li1, Kai Gu1, Hui Wang2

  • 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P.R. China.

Journal of the American Chemical Society
|March 3, 2020

在PubMed 上查看摘要

概括
此摘要是机器生成的。

研究人员开发了空洞的纳米片 (H-Pd NSs) 用于癌症治疗. 这些新型纳米材料结合了光热和光动力学特性,在研究中达到99.7%的瘤抑制率.

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科学领域:

  • 材料科学
  • 纳米技术
  • 生物医学工程

背景情况:

  • 纳米板 (Pd NSs) 在光热治疗中显示出潜力.
  • Pd NS 的光动力学特性在很大程度上是未被探索的.
  • 开发用于癌症治疗的新型纳米材料至关重要.

研究的目的:

  • 制造具有内在光动力学和低氧性能力的空洞纳米板 (H-Pd NS).
  • 研究H-Pd NSs在成像导向的低氧瘤治疗中的应用.
  • 探索可生物降解的贵金属纳米激光剂的设计.

主要方法:

  • 具有活性 (100) 面的H-Pd NSs的无氧化蚀刻策略.
  • 在模拟生理介质中研究H-Pd NS的逐渐降解.
  • 在体外和体内评估H-Pd NS作为光热/光动力学剂.

主要成果:

  • 用一维纳米孔和活跃 (100) 面成功制造了H-Pd NS.
  • 在模拟生理条件下,H-Pd NSs逐渐降解.
  • 在成像指导的低氧瘤治疗中,H-PdNS的瘤抑制率高达99. 7%.

结论:

  • H-Pd NS具有内在的光动力学和低氧性能力.
  • 可生物降解的H-Pd NS是光热/光动力疗法的有效单元剂.
  • 这项工作为设计用于癌症治疗的金属纳米激光剂提供了洞察力.