大麻 (CBD) 产品的不良影响是否是由四大麻 (THC) 污染引起的?
Dirk W Lachenmeier1, Stephanie Habel1, Berit Fischer1
1Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Karlsruhe, 76187, Germany.
F1000Research
|September 16, 2024
概括
Cannabidiol (CBD) 产品的不良影响可能是由于 Δ9-THC 污染,而不是 CBD 转化. 许多基于大麻的CBD产品超过了安全的Δ9THC水平,引发了安全和监管方面的担忧.
科学领域:
- 食品科学与技术 食品科学与技术
- 药理学 药理学是指药理学的学科.
- 监管事务 监管事务
背景情况:
- 大麻素 (CBD) 产品广泛可用,不良影响通常与胃中CBD转化为Δ9-四大麻素 (Δ9-THC) 有关.
- 以前的研究无法在模拟的胃条件下从纯CBD中确认Δ9THC的形成.
- 一个替代假设表明,大麻衍生产品中的残留Δ9THC污染是造成不良影响的原因.
研究的目的:
- 调查假设残留的Δ9THC污染,而不是CBD转化,是导致商业CBD产品的不良影响的原因.
- 为了评估德国市场上可用的基于大麻的CBD产品中D9THC的含量.
- 评估这些产品是否符合欧洲食品法和安全法规.
主要方法:
- 分析了来自德国市场的413种基于大麻的CBD产品,使用液体染色学/并联质谱学 (LC/MS/MS) 和超高压液体染色学/四极飞行时间质谱学 (UPLC-QTOF).
- 在分析产品中量化D9THC度.
- 根据欧洲食品法,评估与D9THC含量,新食品成分,健康声明和标签要求相关的产品不符合性.
主要成果:
- 该研究发现,在413个 (12%) 分析的基CBD产品中,48个 (12%) 含有超过2.5毫克/天的最低观察到的不良影响水平的Δ9THC.
- 在模拟的胃条件下,从纯CBD中没有检测到显著的Δ9THC形成.
- 所有分析的产品都表现出各种不符合欧洲食品法规的情况,包括不安全的Δ9THC水平以及新食品成分,健康声明和标签方面的问题.
结论:
- 报告的一些商业CBD产品的不良影响可能归因于低剂量的D9THC污染,而不是CBD的转化.
- 许多商用CBD产品的安全性和纯度值得怀疑,对于潜在的肝脏和生殖毒性存在重大不确定性.
- 由于食品企业经营者普遍不遵守法规和自我监管不足,因此对于大麻产品有一个强有力的监管框架是至关重要的.
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