在新加坡感染SARS-CoV-2的患者的流行病学特征和临床过程
Barnaby Edward Young1,2,3, Sean Wei Xiang Ong1,2, Shirin Kalimuddin4,5
1National Centre for Infectious Diseases, Singapore.
JAMA
|March 4, 2020
概括
新加坡最初的18名急性呼吸综合征冠状病毒2 (SARS-CoV-2) 患者往往有轻微症状,但有些人需要氧气. 在这项早期的SARS-CoV-2爆发研究中,洛皮纳维尔 - 里托纳维尔治疗显示出不同的结果和副作用.
科学领域:
- 传染性疾病
- 病毒学
- 公共卫生
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 在2019年底出现,导致全球大流行.
- 了解SARS-CoV-2的初始临床和流行病学特征对于有效的管理至关重要.
研究的目的:
- 描述新加坡与SARS-CoV-2的初步经验.
- 调查早期病例的流行病学,临床特征和管理.
主要方法:
- 18名PCR确诊的SARS-CoV-2感染患者的描述性病例系列.
- 收集的数据包括临床,实验室和放射学发现,病毒泄露和治疗结果.
- 随访时间为2020年2月25日.
主要成果:
- 大多数患者 (67%) 患上上呼吸道感染; 33% 需要补充氧气,2 位患者需要重症监护.
- 在83%的患者中观察到长时间从鼻流出病毒 (≥7天).
- 病毒在便和血液中被检测出来, 洛皮纳维尔- 里托纳维尔治疗的结果和不良反应各不相同.
结论:
- 在新加坡,早期的SARS-CoV-2感染通常呈现为轻度呼吸道疾病.
- 临床结果各不相同,用洛皮纳维尔- 里托纳维尔治疗的疗效和显著的副作用各不相同.
- 这项研究提供了SARS-CoV-2的初始临床谱和管理挑战的见解.
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