碳酸结合和疏水效应迫使分子进入小空间
Faiz-Ur Rahman1, Demeter Tzeli2,3, Ioannis D Petsalakis2
1Center for Supramolecular Chemistry & Catalysis and Department of Chemistry, College of Science, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
Journal of the American Chemical Society
|March 4, 2020
概括
研究人员使用基键开发了水稳定的超分子囊. 这些新的囊用二二醇功能化,在水性环境中具有选择性结合和稳定性,为新的应用铺平了道路.
科学领域:
- 超分子化学
- 材料科学
- 有机化学
背景情况:
- 超分子囊作为研究狭窄空间中的分子行为的关键模型.
- 现有的囊设计通常面临水性稳定性的局限性,阻碍其在生物和环境系统中的应用.
- 素结合为构建强大的超分子架构提供了一个有前途的非共价相互作用.
研究的目的:
- 合成和表征使用素结合增强水稳定性的新型超分子囊.
- 调查这些囊与D2O中的各种疏水和两分子的宿主-客人复合行为.
- 探索这些水稳定囊在选择性分子识别和封装中的潜在应用.
主要方法:
- 用Resorcin[4]arenes的2,1,3-二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二
- 固态单晶X射线衍射以确定囊的结构组合.
- 在D2O中进行质子核磁共振 (1H NMR) 光谱,以研究宿主-客体复杂度和结合性.
主要成果:
- 通过Se·N基键成功合成了含有2,1,3-二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二三二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二
- 在D2O中证明了与各种客体 (例如,n-hexane,cyclohexane carboxylic acid,n-dodecane) 的宿主-客体复合体形成,表现出不同的静态度 (1:1, 2:1, 2:2).
- 观察到选择性客体吸收 (例如,环相对于) 和囊复合物的显著稳定性与环碳酸无水化在水中超过两周.
- 确定了疏水力和客-客结合作为水溶液组件的关键稳定因素.
- 计算表明,二二醇壁提供了一个独特的微环境,具有高磁性异构性,补充了客C-H键.
结论:
- 碳素结合有效地从功能化腔体中创建稳定的超分子囊.
- 合成的囊表现出可调节的宿主-客体化学和选择性分子识别能力.
- 二甲壁的独特电子和结构特性有助于囊的稳定性和结合特征.
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