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线粒体应激通过OMA1-DELE1-HRI通路传递给细胞质

Xiaoyan Guo1,2, Giovanni Aviles1,2, Yi Liu3

  • 1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.

Nature
|March 6, 2020
PubMed
概括

线粒体应激激活了OMA1-DELE1-HRI通路,通过eIF2α酸化传递信号来诱导ATF4. 这一途径对于哺乳动物细胞的综合应激反应至关重要.

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