在超重或肥胖的2型糖尿病成年人中,强化生活方式干预,健康状况和体重指数与心脏衰竭风险的关联:从AHEAD试验的角度分析
在PubMed上查看摘要
概括
此摘要是机器生成的。强化生活方式干预并没有降低2型糖尿病心力衰竭的风险. 然而,较高的心呼吸能力和体重减轻与心力衰竭风险较低有关.
科学领域
- 心脏病学
- 内分泌学
- 预防医学
背景情况
- 2型糖尿病 (T2DM) 显著增加心力衰竭 (HF) 的风险.
- 生活方式干预和健康变化对T2DM中HF风险的影响尚未完全理解.
研究的目的
- 评估强化生活方式干预对2型糖尿病患者心力衰竭 (HF) 风险的影响.
- 评估心脏呼吸能力 (CRF) 和体重指数 (BMI) 与HF风险的关联,包括随时间的变化.
主要方法
- 来自Look AHEAD试验的数据分析,其中包括5109名没有流行HF的T2DM参与者.
- 使用时间到事件分析和多变量调整的Cox模型来评估与生活方式干预相关的HF风险,基线CRF,BMI及其纵向变化.
主要成果
- 与标准治疗相比,强化生活方式干预并没有显著改变HF风险 (HR,0. 96;95% CI,0. 75- 1. 23).
- 较高的基线CRF与显著降低的HF风险相关 (第2期HR,0. 61;第3期HR,0. 38).
- 随着时间的推移,CRF的改善和体重减轻与HF风险的降低有关 (HR每10%的CRF增加,0. 90;HR每10%的BMI下降,0. 80).
结论
- 在T2DM患者中,强化生活方式干预并没有降低HF风险.
- 在该群体中,基线CRF较高,CRF持续改善和体重减轻与HF风险较低有关.
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