在Drosophila视觉系统中的行为个性的神经发育起源
Gerit Arne Linneweber1,2,3, Maheva Andriatsilavo1,2,3, Suchetana Bias Dutta1,2,3
1Institut du Cerveau et de la Moelle Epinière (ICM)-Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France.
Science (New York, N.Y.)
|March 7, 2020
概括
大脑连接的变化, 不仅仅是基因, 塑造行为. 大脑发育中的随机噪音影响了如何向物体方向的个体差异,
科学领域:
- 神经科学
- 行为遗传学
- 发育生物学
背景情况:
- 行为个性传统上是由基因组与经验解释的.
- 非遗传性发育"噪音"对行为变化的影响在很大程度上尚未被探索.
- 了解个体行为差异的来源至关重要.
研究的目的:
- 研究在发育过程中大脑连接中随机变化的作用,作为行为个性的来源.
- 探索神经回路中的解剖不对称性与特定行为之间的联系.
- 为了确定操纵神经线路不对称是否会影响行为表现.
主要方法:
- 使用Drosophila melanogaster (果) 作为一个模型生物.
- 专注于背部集群神经元 (DCN) 视觉电路,已知涉及到对象定向.
- 量化了DCN布线不对称性的个体间变化,并将其与对象定向行为相关联.
- 实验性地使DCN沉默并诱导DCN不对称性以评估它们对行为的影响.
主要成果:
- 确定了DCN的右/左电线不对称性的非遗传性,个体间的变化.
- 证明DCN电线不对称与个体向视觉对象的能力直接相关.
- 表明沉默DCN消除了解剖不对称与行为之间的联系.
- 发现人工诱导DCN不对称性可以提高对象定向性能.
结论:
- 在发育过程中脑电线的随机变化是个性行为的一个重要因素.
- 神经电路不对称性,特别是在DCN中,为视觉对象定向的个体差异提供了机制.
- 这项研究强调了在理解行为变异时考虑非遗传发育噪音的重要性.
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