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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.4K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Protein Glycosylation01:25

Protein Glycosylation

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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相关实验视频

Updated: Dec 26, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
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Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

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一中继糖化

Xiong Xiao1, Jing Zeng1, Jing Fang1

  • 1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, People's Republic of China.

Journal of the American Chemical Society
|March 10, 2020
PubMed
概括

一种使用单个激活剂的新型单继电糖化方法有效地形成了两种糖化键. 这种方法简化了复杂的寡糖合成,使得天然产品可以快速获得.

更多相关视频

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

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相关实验视频

Last Updated: Dec 26, 2025

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Published on: September 6, 2019

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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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科学领域:

  • 有机化学
  • 碳水化合物化学
  • 合成化学

背景情况:

  • 寡糖合成对于理解生物过程至关重要.
  • 传统的方法通常需要多个步骤和保护小组.
  • 开发高效和多用途的糖化策略仍然是一个关键挑战.

研究的目的:

  • 建立一个新的单继电糖化协议.
  • 用单个激活剂形成两个甘油酸键.
  • 证明该方法在合成复杂的寡糖和自然产品中的实用性.

主要方法:

  • 使用现场生成的循环硫离子作为中继激活器.
  • 使用单一等效的三无水化物进行激活.
  • 将该协议应用于多种类型的糖构造基质.

主要成果:

  • 在单个中成功构建了两种甘氨酸键.
  • 已证明对线性和分支寡糖的广泛基质的适应性.
  • 实现了天然产物 kankanoside F 和 merremoside D 的快速合成.

结论:

  • 开发的单继电糖化是一种高效和有利的方法.
  • 该协议简化了复杂的寡糖的合成.
  • 这一策略为获取生物相关的糖化物提供了有价值的工具.