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相关概念视频

Isomerism02:43

Isomerism

22.8K
Isomers are molecules with the same molecular formula but different structural arrangements. Isomers can be further classified into constitutional isomers and stereoisomers. Constitutional isomers differ in the connectivity of their constituent atoms. For example, 2-butanol and diethyl ether are constitutional isomers, as they have the same chemical formula, C4H10O, but differ in the connectivity of the carbon and oxygen atoms. Constitutional isomers have different physical and chemical...
22.8K
Stereoisomerism02:52

Stereoisomerism

13.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
13.7K
Stereoisomers02:32

Stereoisomers

17.3K
On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to...
17.3K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

10.8K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
10.8K
Structural Isomerism02:34

Structural Isomerism

21.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.4K
Constitutional Isomers of Alkanes02:18

Constitutional Isomers of Alkanes

21.6K
Organic compounds of the same molecular formula can have different structural formulas called constitutional isomers, and the phenomenon is known as constitutional isomerism. Alkanes with four or more carbons showing multiple structures with the same molecular formula thereby exhibit constitutional isomerism.
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the...
21.6K

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相关实验视频

Updated: Dec 26, 2025

Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

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分解和使用:用于诊断和治疗的结构异构体

Yingying Ning1, Yi-Wei Liu1, Zi-Shu Yang1

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.

Journal of the American Chemical Society
|March 17, 2020
PubMed
概括

这项研究引入了一种使用相关的氨酸区域异构体的新方法. 一种异构体可实现近红外成像,而另一种异构体则可促进光动力疗法 (PDT),为联合诊断和治疗提供新的策略.

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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
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科学领域:

  • * 药物化学和分子成像
  • * 纳米技术和生物医学工程

背景情况:

  • *目前的治疗药物往往涉及复杂的合成和不同剂量的诊断和治疗要求.
  • * 将诊断和治疗功能整合到一个单一的分子实体,在医学上提出了重大挑战.

研究的目的:

  • * 开发一种使用密切相关的类区域异构体的新治疗策略.
  • * 展示这些区域异构体及其 (III) 复合物的独特诊断和治疗能力.

主要方法:

  • * 通过1,3-双极循环添加合成类区域异构体.
  • *用于诊断和治疗的 (III) 复合物的形成.
  • 在体外和体内对成像和光动力疗法的有效性进行评估.

主要成果:

  • * 作为其 (III) 复合体的*cis*异构体,具有适用于近红外 (NIR) 成像的发光.
  • 作为其 (III) 复合体的*trans*异构体,有效地产生用于光动力学治疗 (PDT) 的单片氧,具有良好的量子产量.
  • * 这两种异构体表现出互补的生物功能,通过体外和体内实验验证实.

结论:

  • * 可以分离密切相关的类区域异构体,以执行不同的诊断 (成像) 和治疗 (PDT) 功能.
  • 这项研究提出了一个新的范式,用于创建对的分子集,以实现有效的神经测试应用.
  • * 这些发现突出了使用异构化合物在诊断和治疗方式之间切换的多功能方法.