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活细胞,组织和动物中的功能材料的基因向化学组合

Jia Liu¹, Yoon Seok Kim², Claire E Richardson³

¹Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)

|March 21, 2020

概括

科学家们通过基因编程神经元来合成导电聚合物,在生物系统中创造功能性的合成材料. 这种新的生物组装方法保护了细胞的活力,并调节了动物的行为.

科学领域:

生物材料工程
合成生物学
神经科学

背景情况:

多细胞生物系统的复杂性超出了人类的设计能力.
活细胞可以通过细分特定的化学物质来制造合成材料.

研究的目的:

通过遗传指导活神经元来引导电能聚合物的合成.
探索利用细胞机械来创造复杂的功能结构的潜力.

主要方法:

工程酶向与聚合物化学的整合.
特定神经元在等离子膜上进行现场聚合物的遗传指令.
在自由移动的动物中进行电生理和行为分析.

主要成果:

通过基因编程的神经元成功引导导电和绝缘聚合物的合成.
在聚合物组合后保持神经元活力.
证明了神经元膜性质的重塑和细胞类型特定行为的调节.

结论:

在活神经元中基因定位的聚合物组装是可行的.
这种生物混合方法可以在生物系统中创建功能性材料.
在开发新生物材料和治疗策略方面的潜在应用.

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