COVID-19 和心血管疾病
Kevin J Clerkin1, Justin A Fried1, Jayant Raikhelkar1
1Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.
Circulation
|March 24, 2020
概括
冠状病毒疾病2019 (COVID-19) 影响全球健康,严重急性呼吸系统冠状病毒2 (SARS-CoV-2) 影响心血管健康. 需要进一步研究心脏移植的治疗方法和挑战.
科学领域:
- 心脏病学
- 传染性疾病
- 病毒学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 是由SARS-CoV-2引起的全球流行病.
- SARS-CoV-2利用血管激素转化酶2 (ACE2) 受体进入细胞.
- COVID-19 显著影响已有心血管疾病的患者,心肌损伤的患病率显著.
研究的目的:
- 调查ACE2在COVID-19发病过程中的作用.
- 探索ACE抑制剂 (ACEi) 和血管激素受体阻断剂 (ARB) 在COVID-19患者中的影响.
- 为应对COVID-19对心脏移植所带来的挑战.
主要方法:
- 审查有关COVID-19,SARS-CoV-2和心血管影响的当前文献.
- 对心肌损伤和ACE2受体参与的患者数据的分析.
- 讨论治疗策略和移植方案.
主要成果:
- 在COVID-19患者中患有心血管疾病和心肌损伤的高发病率.
- 已确定ACE2受体是SARS-CoV-2的主要入口点.
- 关于ACEi和ARB在COVID-19管理中的作用仍然存在不确定性.
- 在心脏移植中,COVID-19 复杂化了供体选择,免疫抑制和移植后护理.
结论:
- COVID-19对心血管健康构成重大风险,包括心肌损伤.
- 需要进一步研究ACE2在感染中的作用和相关药物的影响.
- 心脏移植方案需要适应COVID-19受影响的患者.
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