在马来亚松鼠中识别与SARS-CoV-2相关的冠状病毒
Tommy Tsan-Yuk Lam1,2, Na Jia3, Ya-Wei Zhang3
1Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, P. R. China.
Nature
|March 29, 2020
概括
马来亚松鼠携带与SARS-CoV-2相关的冠状病毒. 这些发现表明松鼠可能是新型冠状病毒的中间宿主,强调需要将它们从市场中移除以防止动物传播.
科学领域:
- 病毒学
- 动物传染病
- 野生动物保护
背景情况:
- SARS-CoV-2 (严重急性呼吸道综合征冠状病毒2) 的出现导致全球病毒性肺炎爆发.
- 最初的疫情与中国武汉的一个市场有关,野生动物被怀疑是动物感染的来源.
- 虽然蝙蝠被认为是可能的储存宿主,但SARS-CoV-2的中间宿主仍然未被确定.
研究的目的:
- 为了确定SARS-CoV-2的潜在中间宿主.
- 调查马来在新冠病毒传播中的作用.
主要方法:
- 在马来亚松鼠 (Manis javanica) 中发现的冠状病毒的基因组测序.
- 分析与松鼠相关的冠状病毒与SARS-CoV-2的遗传相似性,特别是在受体结合领域.
主要成果:
- 在中国南部捕获的马来亚松鼠中发现了与SARS-CoV-2相关的冠状病毒.
- 这些松鼠冠状病毒代表了两个不同的亚系.
- 一个谱系显示其受体结合域与SARS-CoV-2具有显著的相似性.
结论:
- 马来亚松鼠携带多种与SARS-CoV-2密切相关的冠状病毒.
- 鱼被确定为新冠病毒出现的潜在中间宿主.
- 建议将松鼠从湿地市场移除以减轻动物传播的风险.
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