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治愈艾滋病毒:寻求准和清除持久感染

David M Margolis¹, Nancie M Archin², Myron S Cohen³

¹UNC HIV Cure Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Epidemiology, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC 27599, USA.

|March 30, 2020

概括

研究人员正在探索治疗人类免疫缺陷病毒1型 (HIV-1) 感染的新方法. 结合抗逆转录病毒疗法与潜伏逆转疗法和免疫疗法,

科学领域:

病毒学
免疫学
传染性疾病

背景情况:

人类免疫缺陷病毒1型 (HIV-1) 感染仍然是一个慢性疾病,尽管有效的抗逆转录病毒治疗 (ART).
艾滋病毒-1的持续性需要制定旨在彻底消灭或治愈病毒的策略.
与终身HIV-1治疗相关的耻辱和负担很大.

研究的目的:

审查基础研究和艾滋病毒治疗研究的最新进展.
突出消除持久性HIV-1感染的新疗法.
讨论艾滋病毒治愈策略对全球艾滋病毒流行病的潜在影响.

主要方法:

对艾滋病毒治愈研究现有文献的审查,包括潜伏逆转剂和免疫疗法.
对临床试验进展和现场新发现的分析.
结合发现与ART交付和艾滋病毒预防方面的进展.

主要成果:

目前的艾滋病毒治疗研究还处于早期阶段,
与潜伏期逆转和免疫疗法的联合治疗显示出病毒清除的潜力.
抗逆转录病毒治疗和预防方面的进展是治疗策略的关键补充.

结论:

开发有效的艾滋病毒治疗策略是减轻艾滋病毒大流行负担的关键目标.
未来的疗法有可能消除与慢性HIV-1感染相关的终身耻辱和治疗.
持续的研究和临床转化对于实现HIV-1的功能治愈或根除至关重要.

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