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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
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化物抑制CLC抗载体的分子基础

Maria Gabriella Chiariello1,2, Viacheslav Bolnykh3, Emiliano Ippoliti1,2

  • 1Institute for Advanced Simulation (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.

Journal of the American Chemical Society
|April 3, 2020
PubMed
概括

化物通过结合大肠杆菌的选择性过器ClC-ec1中的质子来抑制化物通道功能. 这种相互作用通过改变蛋白质构成来阻止质子运输.

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