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Updated: Dec 25, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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在DNA断裂上化PARP-1的结构基础

Levani Zandarashvili1, Marie-France Langelier2, Uday Kiran Velagapudi3

  • 1Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|April 4, 2020
PubMed
概括

在DNA断裂处捕获PARP-1的多基聚合酶 (PARP-1) 抑制剂. 研究人员开发了一种新的抑制剂,可保留PARP-1,增强癌细胞的杀死力,并提供新的临床选择.

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