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细胞类型特异性内相互作用揭示了MS中的寡细胞机制

Daniel C Factor1, Anna M Barbeau2, Kevin C Allan1

  • 1Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Cell
|April 5, 2020
PubMed
概括

多发性硬化症 (MS) 涉及免疫攻击,但这项研究发现中枢神经系统 (CNS) 细胞中的新遗传风险,特别是寡细胞,影响髓修复,并建议新的治疗点.

关键词:
在GWAS细胞类型表观遗传学遗传风险多发性硬化症体细胞外部变种人口遗传学转基因化转录暂停释放

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