在瑞典人口中患有腹腔疾病和死亡风险之间的关联
Benjamin Lebwohl1,2, Peter H R Green1, Jonas Söderling3
1Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, New York.
JAMA
|April 8, 2020
概括
结核病 (一种不耐) 与持续的,增加的死亡风险有关,即使是最近的诊断. 这种风险存在于所有年龄段,并且长期存在,强调需要持续管理.
科学领域:
- 胃肠病学
- 流行病学
- 公共卫生
背景情况:
- 结核病 (CD) 与长期死亡率的增加有关.
- 在现代CD诊断时代,死亡风险变化存在不确定性.
研究的目的:
- 评估结核病诊断与死亡风险之间的关联.
- 评估瑞典的风险是否随着时间的推移而发生变化.
主要方法:
- 在瑞典 (1969-2017年) 开展的一项基于人口的队列研究发现了49829名CD患者.
- 基因病理学证实了CD诊断;个体与多达5个对照组相匹配.
- 分层考克斯比例模型分析了所有原因和特定原因的死亡率.
主要成果:
- 患者的整体死亡风险增加了21% (HR,1. 21).
- 观察到心血管,癌症和呼吸道疾病的死亡风险增加.
- 诊断后的第一年风险最高,但持续超过10年和最近的诊断 (2010年至2017年).
结论:
- 结核病的诊断与较小但具有统计意义的死亡风险增加有关.
- 这种增加的风险是持久的,即使在最近的诊断时代也存在.
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