Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.4K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.0K
Overview
83.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.2K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

mRNA-based MRI contrast agent for precise diagnosis of glioma and pseudoprogression.

Cell biomaterials·2026
Same author

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases.

Nature cancer·2026
Same author

Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.

International journal of molecular sciences·2026
Same author

mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression.

Nature biotechnology·2026
Same author

The Society of Thoracic Surgeons 2026 Expert Consensus on the Multimodal Treatment of Pleural Mesothelioma.

The Annals of thoracic surgery·2026
Same author

Dendritic Cell Heterogeneity Tailored to Their Function.

Immunological reviews·2026

相关实验视频

Updated: Dec 24, 2025

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

1.3K

一个保存的树突细胞调节程序限制了抗瘤免疫力

Barbara Maier1,2,3, Andrew M Leader1,2,3, Steven T Chen1,2,3

  • 1The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nature
|April 10, 2020
PubMed
概括

研究人员发现一种新型树突细胞 (DC) 阻碍抗癌免疫疗法. 在这些成熟的免疫调节分子 (mregDCs) 中阻断特定的信号通路恢复了抗瘤免疫力并减少了瘤生长.

更多相关视频

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

7.3K

相关实验视频

Last Updated: Dec 24, 2025

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

1.3K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

7.3K

科学领域:

  • 免疫学
  • 癌症生物学
  • 细胞生物学

背景情况:

  • 检查点封锁疗法已经彻底改变了癌症治疗,
  • 传统的1型树突细胞 (DC1s) 对于启动CD8+T细胞反应至关重要,并且与更好的癌症存活率有关.
  • 在抗检点阻塞的瘤中存在DC1s表明这些病变的DC功能发生了变化.

研究的目的:

  • 调查瘤中树突细胞 (DC) 的功能状态,这些瘤抵抗检查点阻塞.
  • 识别新的DC子集及其在调节抗瘤免疫力的作用.
  • 发现癌症中DC功能障碍背后的分子机制.

主要方法:

  • 在人类和小鼠非小细胞肺癌样本中使用单细胞RNA测序.
  • 一个新发现的DC子集的特征,称为"在免疫调节分子中丰富的成熟DCs" (mregDCs).
  • 与免疫调节和成熟相关的基因表达分析,包括Cd274,Pdcd1lg2,Cd200,Cd40,Ccr7和Il12b.

主要成果:

  • 发现了一种新的DC子组,mregDCs,共同表达免疫调节和成熟基因.
  • 在传统的DC1和DC2中,mregDC程序是在瘤抗原吸收时被诱导的.
  • 在mregDCs中,编程死亡配体1的上调依赖于AXL,而IL-12的产生则受到IL-4信号的负调节.
  • 阻断IL-4增强了mregDC1s的IL-12产生,增加了效应T细胞,并减少了瘤负担.

结论:

  • 一个与瘤抗原吸收相关的调节模块损害了癌症中的DC1功能.
  • 针对mregDCs中的IL-4信号通路可以恢复抗瘤免疫力.
  • 这些发现为提高癌症免疫疗法的有效性提供了潜在的新策略.