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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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通过使用人类ACE2进入SARS-CoV-2的结构和功能基础

Qihui Wang1, Yanfang Zhang2, Lili Wu3

  • 1CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Cell
|April 11, 2020
PubMed
概括

由于关键的残留物变化,SARS-CoV-2的尖端蛋白与人类的ACE2结合得更高. 对SARS-CoV有效的抗体不会与SARS-CoV-2结合,这凸显了病毒的差异.

关键词:
在ACE2中一个 CTD冠状病毒晶体结构免疫性接收器受体结合域

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