2019年新冠病毒病 (COVID-19) 的药物治疗方法:一篇综述
James M Sanders1,2, Marguerite L Monogue1,2, Tomasz Z Jodlowski3
1Department of Pharmacy, University of Texas Southwestern Medical Center, Dallas.
JAMA
|April 14, 2020
概括
目前还没有证实2019年新冠病毒病 (COVID-19) 的有效治疗方法. 正在进行的临床试验对于识别可行的治疗方法来对抗严重急性呼吸系统冠状病毒2 (SARS-CoV-2) 流行病至关重要.
科学领域:
- 病毒学
- 传染性疾病
- 公共卫生
背景情况:
- 由SARS-CoV-2引起的2019年新冠肺炎 (COVID-19) 流行病对全球健康构成了重大挑战.
- 迫切需要有效的治疗和预防药物.
研究的目的:
- 审查目前针对COVID-19有效医疗治疗的证据.
- 确定SARS-CoV-2感染的有前途的治疗点和病原体.
主要方法:
- 审查当前的科学文献和正在进行的临床试验数据.
- 评估潜在治疗的疗效,包括雷梅西维尔,奥塞尔塔米维尔和皮质类固醇.
- 预先存在的疾病和药物 (ACE抑制剂,ARBs) 对COVID-19结果的影响的评估.
主要成果:
- 到目前为止,还没有任何疗法证明对SARS-CoV-2的有效性.
- 雷梅西维尔在体外表现出活性,但需要在随机试验中进一步评估.
- 目前的证据不支持停止服用ACE抑制剂或ARBs.
结论:
- COVID-19 疫情是全球重大健康危机,需要快速生成证据.
- 快速启动临床试验表明,疫情期间能够产生高质量的数据.
- 为了建立有效的COVID-19治疗方法,进一步的研究至关重要.
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