结核性咳
Marcel A Behr1, Paul H Edelstein2, Lalita Ramakrishnan3
1Department of Medicine, McGill University, McGill International TB Centre, Montreal H4A 3J1, Canada.
Cell
|April 18, 2020
概括
一种特定于结核病的脂质SL-1刺激人类和试验猪的咳诱导神经元. 结核菌提取物还激活了参与咳反射的其他神经元,表明复杂的机制.
科学领域:
- 神经科学
- 传染性疾病
- 免疫学
背景情况:
- 咳是结核病的主要症状和传播途径.
- 结核病引起的咳的神经机制尚不完全理解.
- 结核菌 (Mtb) 是结核病的致病原体.
研究的目的:
- 研究Mtb特异性脂质在刺激与咳相关的神经元中的作用.
- 识别MTB成分激活的神经通路,有助于咳反射.
主要方法:
- 人类感知神经元的电生理记录.
- 在几内亚猪模型中进行咳诱导测试.
- 使用Mtb特异性脂质SL-1和Mtb提取物的刺激.
主要成果:
- 特定于Mtb的脂质SL-1直接刺激人类的感知神经元.
- 在几内亚猪中使用SL-1诱导咳.
- Mtb提取物刺激了参与咳反射的感觉神经元和非感觉神经元.
结论:
- Mtb脂质SL-1通过激活感知神经元是结核病诱导咳的关键媒介.
- 额外的Mtb成分会激活其他神经通路,这表明结核病相关的咳有多方面的机制.
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