运动和冠状动脉样硬化:观察,解释,相关性和临床治疗
Vincent L Aengevaeren1,2, Arend Mosterd3, Sanjay Sharma4
1Department of Physiology (V.L.A., T.M.H.E.), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Circulation
|April 21, 2020
概括
中年运动员的冠状动脉化程度较高, 但他们的斑块可能不那么危险. 这篇评论探讨了
科学领域:
- 心脏病学
- 运动医学
- 预防性心脏病学
背景情况:
- 定期运动可以降低心血管疾病的风险.
- 然而,中年及老年运动员的冠状动脉硬化患病率较高,通常以冠状动脉结为衡量.
- 这一发现与运动的一般益处相反.
研究的目的:
- 审查运动对中老年运动员冠状动脉样硬化的影响.
- 了解大量运动对冠状动脉的潜在不良影响.
- 以指导冠状动脉化的运动员的临床治疗.
主要方法:
- 使用计算机断层扫描 (CT) 测量冠状动脉硬化研究的文献综述.
- 运动员与对照者的斑块形态和组成分析.
- 检查运动量与冠状动脉硬化之间的关联.
主要成果:
- 与非运动员相比,运动员,尤其是非常活跃的运动员,患冠状动脉化和动脉硬性斑块的患病率更高.
- 运动员的斑块分析表明,这种成分较为良性,混合斑块较少,只有化斑块较多.
- 这表明运动员的疾病过程或进展可能不同.
结论:
- 虽然运动员可能有更多的冠状动脉化,但斑块特征表明急性心血管事件的风险可能较低.
- 对运动引起的冠状动脉样硬化的机制和临床相关性进行进一步的研究是有必要的.
- 在治疗冠状动脉化的运动员时,医生应考虑斑块组成和临床背景.
相关概念视频
Atherosclerosis III: Management
263
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
263
Exercise and Cardiovascular Response
3.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.7K
Coronary Artery Disease I: Introduction
781
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
781
Coronary Artery Disease IV: Preventive Measures
530
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
530
Coronary Artery Disease V: Interprofessional Care
179
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
179
Coronary Artery Disease II: Pathophysiology
291
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
291


