糖盗版作为4,6-二氧化的合成平台
Yinan Zhang1,2, Jianjun Zhang2, Larissa V Ponomareva2
1Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
Journal of the American Chemical Society
|April 25, 2020
概括
这项研究提出了一种新型的合成策略,使用谱来制造多种功能化单糖. 这种方法有效地产生各种二氧化和相关的糖,包括类抗生素中发现的糖.
科学领域:
- 有机化学
- 碳水化合物化学
- 自然产品合成
背景情况:
- 自然产品如菌素为合成探索提供了复杂的支架.
- 获取多种功能化单糖对于药物化学和药物发现至关重要.
- 现有的合成脱氧糖的方法在范围和立体选择性上可能是有限的.
研究的目的:
- 开发一种高效且不同的合成策略,用于获取广泛的功能化单糖.
- 用天然产品的spectinomycin作为新型糖合成的原料.
- 合成特定的脱氧糖与宏观抗生素结构相关.
主要方法:
- 一个从天然产品spectinomycin开始的合成策略.
- 在2'和3'位置的关键分泌物中分泌物的立体选择性减少.
- 应用开发的方法来合成目标脱氧糖.
主要成果:
- 容易获得所有8种可能的2,3-固态同位素的4,6-二氧化.
- 代表性的3,4,6-三氧化糖和3,4,6-三氧化-3-氨基的合成.
- 成功合成d-和d-desosamine,这是宏类抗生素的关键成分.
结论:
- 描述的合成策略是高效和分歧的,使得功能化单糖的广泛使用成为可能.
- 斯佩克提诺作为产生复杂碳水化合物结构的有价值的原料.
- 这种方法为合成生物活性天然产品中的重要脱氧糖提供了可靠的途径.
相关概念视频
Biosynthesis of Polysaccharides
462
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
462
Sugars as Energy Storage Molecules
9.7K
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
9.7K
Glycolysis: Preparatory Phase
16.2K
In cellular metabolism (the complete breakdown of glucose to extract energy), glycolysis is the first step. Glycolysis takes place in the cytoplasm of both prokaryotic and eukaryotic cells. Glucose enters heterotrophic cells in two ways. One method is through secondary active transport, where the transport takes place against the glucose concentration gradient. The other mechanism uses a group of integral proteins called GLUT proteins, also known as glucose transporter proteins. These...
16.2K
Energy-requiring Steps of Glycolysis
170.9K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
170.9K
Other Glycolytic Pathways
684
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
684
Dehydration Synthesis
147.8K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
147.8K


