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Qiang Gao¹, Linlin Bao², Haiyan Mao³

¹Sinovac Biotech Ltd., Beijing, China.

Science (New York, N.Y.)

|May 8, 2020

概括

一种试验级别的非活化SARS-CoV-2疫苗候选物PiCoVacc在动物模型中成功产生了中和抗体. 这种疫苗显示出对的广泛菌株中和防治COVID-19挑战的潜力.

科学领域:

* 病毒学和免疫学
* 疫苗开发

背景情况:

*由SARS-CoV-2引起的COVID-19大流行,由于缺乏特定的治疗方法,迫切需要开发疫苗.
*SARS-CoV-2的新奇性在制造有效和安全的疫苗方面带来了挑战.

研究的目的:

* 开发和评估PiCoVacc,这是一种纯化的非活化SARS-CoV-2疫苗候选剂,其免疫性和保护性有效性.
* 在临床前模型中评估中和抗体反应和对SARS-CoV-2挑战的保护.

主要方法:

* 试验性生产纯化无活化SARS-CoV-2病毒 (PiCoVacc).
* 用PiCoVacc对老鼠,大鼠和非人类灵长类动物进行免疫接种.
* 对多种SARS-CoV-2菌株的中和抗体标位和中和幅度的评估.
* 挑战对的研究,以评估疫苗的有效性和安全性,包括抗体依赖增强.

主要成果:

* PiCoVacc 在小鼠,大鼠和非人类灵长类动物中诱导了SARS-CoV-2 特定的中和抗体.
* 诱导的抗体中和了 10 种代表性的 SARS-CoV-2 菌株,表明了潜在的广泛疗效.
* 三次免疫接种 (3或6μg/剂量) 在没有抗体依赖增强的情况下对提供了部分或完全的保护.

结论:

* PiCoVacc 是一个有前途的非活化疫苗候选者.
* 临床前数据支持PiCoVacc的进一步临床开发和人类测试.
* 该疫苗在动物模型中证明了安全性和有效性,因此需要对人类进行试验.

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