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Updated: Dec 22, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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SARS-CoV-2 在 hACE2 转基因小鼠中的致病性

Linlin Bao1,2, Wei Deng1,2, Baoying Huang3

  • 1Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China.

Nature
|May 8, 2020
PubMed
概括

表达人类ACE2 (hACE2) 的转基因小鼠感染了SARS-CoV-2,显示出肺病理和病毒复制. 这种HaaCE2小鼠模型对于开发COVID-19治疗和疫苗至关重要.

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Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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