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在人类重复扩张疾病中脱离转录凝聚物

Shaon Basu1, Sebastian D Mackowiak1, Henri Niskanen1

  • 1Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

Cell
|May 11, 2020
PubMed
概括

转录因子 (TF) 的氨基酸重复扩张导致遗传性疾病. 改变这些TF的相位分离会破坏细胞功能,这可能解释疾病机制.

关键词:
激活领域凝结物本质上是无序的区域阶段分离重复扩张综合多样性转录因子转录凝结物

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