接种了SARS-CoV-2的 rhesus 的呼吸系统疾病
Vincent J Munster1, Friederike Feldmann2, Brandi N Williamson1
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
rhesus macaques 患有类似于 COVID-19 (冠状病毒疾病 2019) 的呼吸道疾病,呈现出肺透和高病毒载荷. 这一发现使得 rhesus 成为研究 SARS-CoV-2 病变和开发医疗对策的有价值动物模型.
科学领域:
- 动物医学
- 传染性疾病
- 病毒学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行需要强大的动物模型进行研究.
- 了解SARS-CoV-2的发病性对于开发有效的治疗方法和疫苗至关重要.
研究的目的:
- 建立和描述COVID-19的 rhesus模型.
- 评估 rhesus 适用于研究 SARS-CoV-2 感染和疾病进展.
主要方法:
- rhesus 感染了 SARS-CoV-2.
- 呼吸系统疾病的临床监测和放射性评估.
- 在各种样本类型中检测病毒载荷 (擦拭物,支气管洗,直肠脱落).
主要成果:
- SARS-CoV-2 感染导致 rhesus 的呼吸系统疾病持续 816 天.
- 肺部透,这是人类COVID-19的特征,在肺部放射图中观察到.
- 在鼻子和喉抽样和支气管洗中检测到高病毒载荷,其中一个病例是长时间的直肠泄漏.
结论:
- rhesus 模型复制了大多数人类病例中观察到的中度COVID-19.
- 这种模型将促进对SARS-CoV-2病变的理解.
- rhesus 模型适用于对抗 COVID-19 的医疗对策.
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