视网膜内置调节电路,驱动非光学引入食物
Diego Carlos Fernandez1, Ruchi Komal2, Jennifer Langel2
1National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. diego.fernandez@nih.gov.
Nature
|May 15, 2020
概括
早期视觉系统的发育对于生理节律与食时间表的调整至关重要. 本质上光敏感的视网膜质细胞 (ipRGC) 通过在发育过程中影响IGL-SCN电路来塑造食时间反应.
科学领域:
- 神经科学
- 时间生物学
- 发育生物学
背景情况:
- 每天的光线和食物都会影响日间时间.
- 整合这些信号的神经回路并未完全被理解.
- 本质上对光敏感的视网膜结质细胞 (ipRGC) 将光信息传递给上神经核 (SCN) 和细胞间传单 (IGL).
研究的目的:
- 调查视网膜输入是否调节引入非光学线索,如时间限制的养.
- 确定早期产后ipRGC内化在塑造IGL-SCN循环中的作用.
主要方法:
- 使用了缺乏ipRGC的成年小鼠.
- 检查了晚期ipRGC切除的效果.
- 在成年小鼠中抑制表达神经Y (NPY) 的IGL神经元.
- 评估了食物预测活动.
主要成果:
- 缺乏早期ipRGCs的小鼠表现出受时间限制养的影响.
- 晚期ipRGC切除没有显著的影响.
- 早期的ipRGC内化会影响IGL NPY神经元,指导IGL-SCN电路组合.
- 沉默IGLNPY神经元模仿了早期的ipRGC消灭缺陷.
- 在SCN中抑制IGLNPY终端降低了食物预测活性.
结论:
- 早期产后ipRGC内化对于建立IGL-SCN电路进入时间限制养的能力至关重要.
- ipRGC 影响的发育时间对于非光学昼夜线索的引入至关重要.
相关概念视频
The Retina
73.9K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
73.9K
Photoreceptors and Visual Pathways
8.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.4K
Anatomy of the Eyeball
9.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.2K
Channel Rhodopsins
3.0K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.0K
Vision
59.1K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
59.1K


