在细胞染色体的晶体网络中通过跳跃转移介质到宏观电子
Jingcheng Huang1,2, Jan Zarzycki1,2, M R Gunner3
1DOE-Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, United States.
Journal of the American Chemical Society
|May 15, 2020
概括
在晶体小四细胞染色体 (STC) 中的电子转移使生物过程能够在微观距离上进行. STC 格子促进了高效,定向的电子流,表明了生物电子应用的潜力.
科学领域:
- 生物物理
- 生物化学
- 材料科学
背景情况:
- 电子转移 (ET) 对生物功能至关重要,对于短距离 (1-2 nm) 已建立理论.
- 在生物系统中,ET过程的缩放到微观距离仍然不太清楚.
研究的目的:
- 通过使用晶体小四细胞染色体 (STC) 来研究介质距离到微观距离的电子转移.
- 评估基于STC的纳米线在无氧呼吸等生物应用中的可行性.
- 测试短距离ET理论对更长,连续的ET途径的适用性.
主要方法:
- 形成3D氧化回收中心的晶体STC网格的生成.
- 在特定的晶体位置注入电子.
- 监测电子再分配和ET动态的成像技术.
主要成果:
- 通过STC血红网络的顺序跳跃,在~100μm的距离上演示了ET.
- 估计晶体STC纳米线可以在Shewanella细胞中支持无氧呼吸.
- 观察到的蛋白间ET速率 (10^5 s^-1) 大约是简化的理论预测的100倍.
- 确定晶格可能会增加重组能量,影响中层次ET.
结论:
- 晶体STC平台可以研究中等尺度ET,揭示距离短距离理论的偏差.
- 绝缘晶格保护电子免受氧化,允许有效的电流传输.
- 这些研究结果表明,有助于提高纳米线性能的生物电子材料的设计策略.
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