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Updated: Jun 17, 2026

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell
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Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Published on: July 19, 2015

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人体内分泌细胞的高分辨率mRNA和秘密图谱

Joep Beumer1, Jens Puschhof1, Julia Bauzá-Martinez2

  • 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, Hubrecht Institute, 3584 CT Utrecht, the Netherlands.

Cell
|May 15, 2020
PubMed
概括

研究人员开发了一个新的器官平台来研究人类肠内分泌细胞 (EEC). 这种系统揭示了人类和小鼠之间的EEC的关键差异,为肠道激素的调节和功能提供了洞察力.

关键词:
通过CRISPR介导的 knockin肠内分泌细胞光标签激素的使用人类在肠道有机物蛋白质组学机密学单细胞地图

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Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets11:34

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

Published on: July 18, 2019

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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

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相关概念视频

Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing specific...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...