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感染狗的SARS-CoV-2

Thomas H C Sit¹, Christopher J Brackman¹, Sin Ming Ip¹

¹Agriculture, Fisheries and Conservation Department, Government of the Hong Kong SAR, Hong Kong Special Administrative Region, Hong Kong, China.

|May 15, 2020

概括

香港有两只狗感染了导致COVID-19的SARS-CoV-2病毒,这种病毒是通过人与动物之间的传播传播感染的. 两只狗没有出现症状,但需要进一步研究潜在的传染.

科学领域:

动物医学
传染性疾病
病毒学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 导致了从2019年开始的COVID-19大流行.
一种相关的病毒,SARS-CoV,在2003年感染了家禽.
关于 SARS-CoV-2 在家养哺乳动物中的易感性信息有限.

研究的目的:

调查家庭狗对SARS-CoV-2的易感性.
确定SARS-CoV-2是否可以从受感染的人传染给物狗.
分析感染狗的病毒分泌和免疫反应.

主要方法:

实时PCR与反转录用于病毒RNA检测.
血清检测,包括抗体减少和中和测试.
病毒基因组测序和从受感染的动物中隔离病毒.
采样包括鼻子抽样,口腔抽样和血液分析.

主要成果:

来自COVID-19阳性家庭的15只狗中,有2只被证实感染SARS-CoV-2.
在13天的Pomeranian和两次的德国牧羊犬的鼻子抽样中检测到病毒RNA.
从德国牧羊犬的鼻子和口腔抽样中成功分离了病毒.
在狗和相应的人类病例中发现了相同的病毒遗传序列,支持人对动物的传播.
这两只受感染的狗表现出抗体反应,但仍然无症状.

结论:

这项研究提供了SARS-CoV-2在家养狗中从人类传播给动物的证据.
这项研究中感染的狗无症状,这突显了疾病检测的潜在挑战.
需要进一步调查,以了解狗有可能将SARS-CoV-2传播给其他动物或人类.

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