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新型蛋白质设计可精确诱导RSV中和抗体

Fabian Sesterhenn1,2, Che Yang1,2, Jaume Bonet1,2

  • 1Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.

Science (New York, N.Y.)
|May 16, 2020
PubMed
概括

在动物模型中,新的蛋白质设计产生了新的免疫原,成功地引起了对呼吸道同胞病毒的强烈中和抗体反应. 这种方法使下一代疫苗和治疗方法能够精确地向表位.

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Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...