由SARS-CoV-2感染引起的人类中和抗体
Bin Ju1,2, Qi Zhang3, Jiwan Ge4
1Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
Nature
|May 27, 2020
概括
研究人员分离出针对SARS-CoV-2受体结合域 (RBD) 的强效中和抗体. 这些抗体通过与ACE2竞争来阻止病毒的进入,从而提供潜在的COVID-19疗法.
科学领域:
- 病毒学
- 免疫学
- 结构生物学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行需要有效的干预措施.
- SARS-CoV-2 进入宿主细胞依赖于尖端蛋白的 RBD 与 ACE2 受体的结合.
研究的目的:
- 针对SARS-CoV-2 RBD的单克隆抗体的分离和特征.
- 评估这些抗体的中和能力和机制.
主要方法:
- 从受感染个体中分离和表征206个RBD特异性单克隆抗体.
- 评估抗体中和性竞争.
- 对RBD结合抗体复合物的结构分析.
主要成果:
- 鉴定有力的SARS-CoV-2中和抗体.
- 中和活性与ACE2结合的竞争相关.
- 证明了阻断病毒进入的硬质阻碍机制.
- 观察到与 SARS-CoV 和 MERS-CoV RBD 的交叉反应缺乏.
结论:
- 抗RBD抗体主要是SARS-CoV-2的特定抑制剂.
- 已识别的抗体是针对COVID-19的临床开发的潜在候选者.
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