通过有机酸和相应的酸中间体介导的C-H氨基化
Yunjung Baek1, Anuvab Das2, Shao-Liang Zheng1
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Journal of the American Chemical Society
|May 28, 2020
概括
含有有机的复合物经过二挤出,形成反应性中间体. 这些中间体促进了C-H氨化和亚齐里丁化,展示了它们作为烯组转移试剂的实用性.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 合成化学 合成化学
背景情况:
- 合成和表征的有机化物复合物.
- 研究了这些复合物的反应性,专注于二挤出和随后的转化.
研究的目的:
- 为了研究有机化物结合的复合物的行为.
- 阐明二挤出和烯中间体形成的机制.
- 探索这些中间体在C-H氨基化和亚齐里丁化中作为烯组转移试剂的潜力.
主要方法:
- 合成和表征四坐标的有机化物结合的复合物.
- 光谱和结构分析 (例如,X射线晶体学).
- 反应性研究包括C-H氨基化和亚齐里丁化试验.
- 热分析以确定二挤出温度.
主要成果:
- 发现Organoazide对的结合是氧化还原无害的.
- 从亚利酸添加物中在室温下挤出二,产生高价值酸中间体,使分子间C-H氨基化和亚齐里丁化成为可能.
- 酸添加物需要更高的温度进行N2挤出,形成磁性中间体,通过α-H原子抽象产生Co-imine复合体,固态结构显示Co-nitrenoid中间体.
- 性可访问的二二烯酸盐支架促进了分子内1,3-二极循环添加和C-H氨基化与酸添加物,形成三醇和pyrrolidine产品.
结论:
- 复合物作为产生反应性烯中间体的有效前体.
- 这些中间体的活性,包括C-H氨基化和亚齐里丁化,可以根据亚齐德结构和硬质环境进行调整.
- 该研究强调了这些系统通过基组转移进行选择性功能化的潜力.
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