Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Catalysis02:50

Catalysis

29.9K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
29.9K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.8K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.8K
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

8.8K
Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
8.8K
Nitriles to Amines: LiAlH4 Reduction00:55

Nitriles to Amines: LiAlH4 Reduction

4.4K
Nitriles are reduced to amines in the presence of strong reducing agents like lithium aluminum hydride through a typical nucleophilic acyl substitution. The reaction requires two equivalents of the reducing agent. The reducing agent acts as a source of hydride ions.
As shown below, the mechanism involves three steps. Firstly, the hydride ion acting as a nucleophile attacks the nitrile carbon to form an anion. In the second step, a second equivalent of the hydride ion attacks the anion to...
4.4K
Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

13.8K
Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
13.8K
Preparation of Amines: Reductive Amination of Aldehydes and Ketones01:38

Preparation of Amines: Reductive Amination of Aldehydes and Ketones

3.6K
Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.
3.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Chemical Probes to Reveal the Assembly and Dynamics of Wall Teichoic Acids.

Journal of the American Chemical Society·2026
Same author

Enantioconvergent Chan-Evans-Lam C(sp<sup>3</sup>)-O Coupling: Cu-Catalyzed Asymmetric Benzyl- and Allylborane Oxidation.

Journal of the American Chemical Society·2026
Same author

Manipulating Terminal Iron-Hydroxide Nucleophilicity through Redox.

Journal of the American Chemical Society·2026
Same author

Hydride Transfer Reactivity of an Open-Shell [Fe<sub>3</sub>H]<sup>-</sup> Cluster.

Journal of the American Chemical Society·2025
Same author

Cu-catalyzed enantioconvergent deborylative alkynylation.

Chemical science·2025
Same author

Accessing Square Planar Cobalt Nitrenoid Redox Isomers across Three Oxidation States.

Journal of the American Chemical Society·2025

相关实验视频

Updated: Dec 20, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

10.1K

使用二烯复合物的高效C-H氨化催化

Yuyang Dong1, Ryan M Clarke1, Gerard J Porter1

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|May 29, 2020
PubMed
概括
此摘要是机器生成的。

一种新的催化剂使酸在室温下能够有效地进行分子内C-H氨化. 这种反应通过确定速率的原子抽象步骤进行,形成具有广泛基质范围和功能组容忍度的N-异环.

更多相关视频

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.9K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

相关实验视频

Last Updated: Dec 20, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

10.1K
Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.9K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

科学领域:

  • 有机金属化学
  • 催化剂
  • 有机合成

背景情况:

  • 内分子C-H氨基化是合成N-异环的关键转化.
  • 开发温和高效的C-H功能化催化系统仍然是一个重大挑战.
  • 催化为激活惰性C-H键提供了一个有前途的途径.

研究的目的:

  • 开发一种新型的催化剂,用于分子内C-H氨化.
  • 调查催化系统的范围,化学选择性和功能组耐受性.
  • 阐明反应机制,包括速度决定步骤和催化休息状态.

主要方法:

  • 用二甲支持的催化剂的合成和表征.
  • 探索C-H氨基化的基质范围,包括各种C-H键类型和功能组.
  • 使用核磁共振 (NMR) 光谱,动态同位素效应 (KIE) 测量和艾灵分析的机制研究.

主要成果:

  • 在温和条件下 (室温,0.1-2%摩尔负荷) 的 (AdFL) 基催化剂有效促进分子内C-H氨基化.
  • 该反应具有广泛的基质范围,成功地氨基化,三级,二级和初级C-H键,对较弱的C-H键具有很高的化学选择性.
  • 机械研究揭示了一种速度决定的原子抽象步骤,可能涉及H原子道化,催化剂的静止状态被确定为胺基.

结论:

  • 已开发出一种高效的催化剂,用于分子内C-H氨基化,使N-异环的合成成为可能.
  • 反应在温和条件下进行,并表现出优异的功能组耐受性和化学选择性.
  • 机械学研究为催化循环提供了关键的见解,强调了原子抽象和道的重要性.