新生儿病毒组的逐步组装是通过母乳养来调节的
Guanxiang Liang1,2, Chunyu Zhao2, Huanjia Zhang2
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature
|May 29, 2020
概括
婴儿的肠道
科学领域:
- 微生物学
- 病毒学
- 新生儿健康
背景情况:
- 婴儿的肠道在出生时通常没有病毒,
- 病毒殖民有时会导致新生儿的胃肠道问题.
研究的目的:
- 阐明新生儿病毒群体的逐步组合.
- 研究婴儿肠道病毒群的起源和动态.
主要方法:
- 病毒丰富和整个微生物群落的射击枪转基因组测序.
- 病毒样粒子的光染色.
- 有针对性的微生物分析.
主要成果:
- 病毒殖民发生在不同的步骤中,从先驱细菌的菌体开始.
- 一个月后, 菌体占主导地位;四个月后, 感染人类的病毒增加.
- 母乳养影响病毒群体的组成,配方奶粉养的婴儿表现出更高的人类病毒的丰度.
结论:
- 婴儿肠道病毒殖民是细菌菌体开始的逐步过程,后来受到人类病毒的影响.
- 哺乳对婴儿肠道病毒组的调节起着重要作用.
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