在没有反应的脑损伤患者中,嗅觉信号
Anat Arzi1,2,3, Liron Rozenkrantz4,5, Lior Gorodisky4,5
1Department of Psychology, University of Cambridge, Cambridge, UK. anat.arzi@gmail.com.
Nature
|May 29, 2020
概括
嗅觉反应可以准确地确定严重脑损伤患者的意识. 这种可访问的工具可以预测康复和生存, 帮助做出关键的医疗决定.
科学领域:
- 神经科学
- 神经学
- 感官系统
背景情况:
- 在严重脑损伤患者中诊断意识是具有挑战性的, 错误率高达40%.
- 准确的诊断对于治疗和终生决策至关重要.
- 嗅觉涉及到对兴奋至关重要的脑结构,
研究的目的:
- 研究嗅觉反应作为脑损伤患者意识的非语言,非任务依赖的生物标志物.
- 评估依赖气味的嗅觉在不响应和最小意识状态之间的区别中的实用性.
- 探索嗅觉功能与患者长期结局,包括康复和生存之间的关联.
主要方法:
- 使用嗅觉反应来衡量依赖于气味的嗅觉功能.
- 在患有严重脑损伤的患者中,随着时间的推移反复测量嗅觉反应.
- 与已确定的临床意识状态和长期存活率相关的嗅觉反应数据.
主要成果:
- 在群体层面上,嗅觉反应显著地区分了无反应和最小意识状态.
- 一位最初没有反应的患者的嗅觉反应可靠地预测了未来的意识恢复.
- 嗅觉反应与脑损伤患者的长期存活率有显著的关联.
结论:
- 嗅觉反应作为一个敏感和可访问的生物标志物来评估严重脑损伤的意识.
- 嗅觉功能与唤醒和意识密切相关, 突出其在大脑功能中的重要性.
- 这种方法为监测患者康复和为临床管理提供了有价值的工具.
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