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Updated: Dec 20, 2025

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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基对构造切换调节了Sirt1mRNA的miR-34a向

Lorenzo Baronti1, Ileana Guzzetti1, Parisa Ebrahimi2

  • 1Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

Nature
|May 29, 2020
PubMed
概括

微RNAs (miRNAs) 使用动态开关来增强目标信使RNA (mRNA) 的抑制. 这种切换涉及miRNA-mRNA复合体的结构重组,改善了与人类阿尔戈纳特2蛋白 (Ago2) 的结合.

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