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肝 NADH 减少压力是代谢特征的常见变异的基础

Russell P Goodman1,2, Andrew L Markhard1, Hardik Shah1

  • 1Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.

Nature
|May 29, 2020
PubMed
概括

通过使用细菌酶降低小鼠的细胞NADH/NAD+比率,发现阿尔法-基酸盐是减小压力的标志物. 这种压力将遗传变异与胰岛素抵抗等代谢疾病联系起来.

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