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人类瘤微生物组由特定瘤类型的细胞内细菌组成

Deborah Nejman¹, Ilana Livyatan^1,2, Garold Fuks³

¹Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Science (New York, N.Y.)

|May 30, 2020

概括

人类瘤微生物组虽然难以研究,但根据癌症类型而异,乳腺癌具有丰富的细菌多样性. 瘤内细菌是细胞内的,与瘤特征和治疗反应相关.

科学领域:

癌症学
微生物学
基因组学

背景情况:

人类瘤中细菌的存在已在一个多世纪前被发现.
鉴定瘤微生物群是很困难的,因为它的生物量很低.

研究的目的:

在不同类型的癌症中全面分析瘤微生物组.
研究瘤中的细菌的组成和特征.

主要方法:

分析了7种癌症类型的1526种瘤和相邻的正常组织.
研究的微生物组合,细菌的位置 (细胞内) 和与临床数据的相关性.

主要成果:

每种瘤都有不同的微生物组特征.
乳腺癌表现出特别丰富多样化的瘤微生物组.
瘤内细菌主要是细胞内,在癌症和免疫细胞中发现.
在瘤内细菌,瘤亚型,吸烟状态和免疫治疗反应之间观察到相关性.

结论:

瘤微生物组是一个复杂的,癌症类型特定的实体.
瘤内细菌是影响瘤生物学和治疗结果的潜在因素.

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